It depends on the disability, the magic, and the DM's interpretation, I suppose. Lesser restoration is kind of a cure-all, gets rid of disease, poison, blindness, deafness, and paralysis, and 'disease' in particular might cover a pretty wide swath. Greater restoration can end effects that reduce ability scores or hit point maximums, which might include chronic conditions or congenital birth defects not directly linked to a disease. Regeneration can grow back missing body parts. Anything that these spells don't cover, Wish (and Divine Intervention) almost certainly would, but you'd be hard-pressed to find someone who could and would cast it.

No spell explicitly says it, but I kinda feel like Regeneration might resolve that concern. It's the go-to in the DMG for missing eyes and limbs. General high level healing (6+) will resolve scars, which one can argue that they should also resolve born stuff like epilepsy and the like since those are (kinda) lasting injuries akin to scars. Beyond that a case can definitely be made for Resurrection and it's ability to restore missing body parts. Feel like bringing someone back to life is a big step beyond just curing their paraplegia. Heck, there's an argument for Greater Restoration as well considering it resolves anything that lowers max HP or ability scores. Ultimately those are up to DM ruling but I doubt most would say no.

Then of course there's just straight up Wish but that's a whole nother thing.