@hedge typewise seems cool

Clip Studio Paint IIt was way ahead than any commercial or FOSS alternative. Especially if you're illustrator or comic artist working in specialized workflow (East Asia and SEA industry).

Tried Krita back then, but still lacks a lot of major important feature and customizable UI layout.

I feel LaTeX is not a replacement for inDesign. It would be a replacement for something like word. maybe try scribus?

Obsidian. Plain text files with as many or as few plugins as you want. All versions of the app look and behave the same (other than mobile, but at least android is kinda close). Nothing stored in a database file, no manipulation of the text files themselves (looking at you, Joplin). I'm open to another option but so far, nothing is as elegant and platform agnostic as Obsidian.