From the headline:

The new U7i instances are designed to support large, in-memory databases including SAP HANA, Oracle, and SQL Server.

These are huge instances packing nearly a thousand vCPUs and a dozen TBs of RAM. Small supercomputers, basically.

Fans of monoliths scaling horizontally will love these.

No word on how much AWS charges for it though. I'm sure that the price tag will also result in some horizontal scaling to fit the extra digits.