If you've got interest in deep simulation mechanics you can check out Cataclysm: Dark Days Ahead. It's FOSS and, last I checked, still has an active developer community.

Technically not... exactly a rogue like, but:

Deus Ex w/ Randomizer Mod and PermaDeath.

You can set it up fairly easily the Steam version of DX and the Revision Mod, which at this point is basically all the most popular DX mods, reconfigured to play nice with each other and be as mutually compatible as possible.

Someone already mentioned Caves of Qud, that one is amazing, Noita is really good, also StarSector is functionally a roguelike but in space.

Also No Mans Sky is basically a rogue like if you turn on permadeath, kick the difficulty up.

A couple weirder Rogue-lite suggestions:

Against the Storm is a Rogue-lite City Builder, which sounds like 2 things that shouldn't go together but works surprisingly well. It has a generous demo on Steam that lets you freely play up to level 6 or something in the standard biome, so give it a try

Shape-Hero Factory is a Rogue-lite Factory Builder. Another weird combination that is surprisingly effective. It's in Early Access so there's a lot of features that are still planned, but you can do full runs and go up to I think Ascension 6. It had a demo during nextfest, not sure if the demo is still there.

Heat Signature

If you can still download the legacy version of Dwarf Fortress from Bay12Games website, Adventure Mode is the best rouge like I've ever played. It's not yet in the Steam version, though.

For a more action-oriented rogue like, I find Returnal to be fun as hell. Roguelike bullet hell 3rd person shooter, with a pretty intriguing story line if you manage to actually get all of it (finding story bits is as random as everything else).

Edit: Er... They're on PC, though. DF could run on pretty much anything; returnal might need a decent gaming rig (or a PlayStation).

Ants Took My Eyeball - Pixel graphics, awesome soundtrack, ridiculous premise. One my favorite roguelites ever. Similar to Dead Cells and Noita.

Since you love Slay The Spire, you should try Balatro •<|:)€ ♤♡◇♧!

It's the titular "Poker Rogue-lite" that's taken the world by storm, and it certainly knows how to up the ante!

Trailer.

Mobile Trailer.

Mobile release.

Sounds like you might be into top-down roguelites. Enter the Gungeon, Binding of Isaac, and Nuclear Throne come to mind.

As for games that I would recommend because I just like them, I would recommend checking out Noita, which is a physics simulation/falling sands roguelite. It's pretty hit-or-miss, but if you like tinkering, you might like it. I'm also pretty partial towards Crypt of the Necrodancer, which is a rhythm/full roguelike genre mash. The full roguelike nature of the game makes it harder to get into initially but once you get the hang of it, it's pretty fun

Like most others said. Dead Cells and Binding of Isaac are the top dogs. No matter what else I play I always circle back to one of those two eventually and get sucked in again. But some other lesser known ones that are good are:

Cursed to Golf - 2d golfing roguelike, no combat or anything. There’s a bunch of different cards to make the ball do different stuff. From a rocket ball you control after hitting to an ice ball that’ll freeze water hazards to a drill so you can tunnel through walls.

Oblivion Override - 2d with fast combat and a lot of perks and weapons that change things up. Perks from different “trees” have synergies that are a lot of fun.

Rogue Prince of Persia - 2d parkour style combat made by the folks that did most of Dead Cells post launch updates, still in early access but still fun.

Soundfall - not a true roguelike, top down rhythm shooter with random loot.

BlazBlue Entropy Effect - 2d with a boatload of different classes, different elemental perks that synergize and each class has different perks to add new melee combos

Curse of the Dead Gods - isometric with slower parry based combat, has some mechanics with light and dark that some folks don’t like. If there isn’t a light source nearby you can’t see traps and take extra damage but you can pull a torch out to light braziers or enemies on fire to illuminate the area.

Ravenswatch - same people that made Curse of the Dead Gods. Isometric with different classes and online co-op.

Voidigo - top down shooter with unique art and sound design. Lot of weapons and four or five different characters with unique abilities.

Have a Nice Death - 2d melee with nice movement, mechanics don’t seem as deep as others but still fun.

Dandy Ace - isometric with ranged combat. Magician that throws cards around, good selection of abilities.

Patch Quest - top down, hard to explain this one, might wanna watch a video to see how it plays.

Devil Slayer Raksasi - top down with a lot of elemental effects. Haven’t spent much time with it though.

Well this got a bit longer than I meant but they’re all solid, not sure if they’re all on Switch though.

One more, not a roguelike at all but Switch exclusive and a surprisingly awesome game. Golf Story, check it out.

Dead Cells is fun. It has an end tho, but it's difficult getting there on the higher difficulties. I also liked children of morta, has a story mode and roguelite mode

Hollow Knight