Yeah, and this only gets worse with bigger monitors. Want to use that 43" TV as Monitor #3? Wigglin' isn't going to help.

Real users give up and start using keyboard shortcuts to move crap around until they find it again.

Or just get a wireless gaming mouse with adjustable DPI, crank it up to 11 billion, and try to catch it doing near lightspeed as it goes through all four monitors at once. The only drawback is that, according to physics, it will likely have experienced time dilation, which means your mouse cursor has aged significantly in the short time it was in flight.