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A year of uv: pros, cons, and should you migrate
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That's pretty much the conclusion: you should try uv first, and there's a small chance it doesn't work for you and you're not willing to fix it, or it's out of your hands.
Examples include legacy projects and companies that don't allow it (but I do question how they'd even enforce this, and how developers can even do their jobs if they can't run binaries at the user level).