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Windows 11 has made the “clean Windows install” an oxymoron
(arstechnica.com)
This is a most excellent place for technology news and articles.
The main issue comes when the game is using proprietary stuff. Like I found getting Kingdom Hearts to run at all was a pain in the arse because of it using a proprietary codec for it's cutscenes.
I also found Hand of Fate 2 had some weird rendering issues with certain graphics settings.
And if you want to do Ray tracing or HDR you're currently out of luck.