Like others have said, the rules are... bad. Especially the latest edition. A couple of the older editions are "favorites," but still mixed bags, and lots of people just take the setting and use it in another system entirely.

There's a Shadowrun actual play podcast called NeoScum that I loved (now concluded), and it began with "It's like D&D mixed with Bladerunner!" and ended with "Fuck this, fuck Shadowrun, the universe rearranges itself so we can play a different game." They even had a goofy recurring bit they would do whenever they had to stop play to look up rules or calculate something, which happened constantly. It's also not a player issue, since they've switched to Call of Cthulhu for another story (Gutter) and just don't have that problem.