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xkcd #3126: Disclaimer
(imgs.xkcd.com)
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Information entropy. You need roughly as many syllables to explain the same concept with mono- or disyllabic English words as you do with a scientific polysyllable. Admittedly, some of it is "I know this word! See how smart I am!", but another part is how much more fluid it is to say. "Monosyllabic" rolls off the tongue a lot more easily than "having only one sound".
(The funny answer here would have been "No.")
On top of all that, monosyllabic is accurate to the intended meaning while "having only one sound" is not: a single syllable word often comprises multiple phones and/or phonemes.