I'm most cases, a consecutive run of RTL or neutral characters would be rendered RTL, while the rest would be rendered LTR. However, if it's within a RTL paragraph, this would be reversed.

For example, the following two paragraphs have the same path, but the surrounding text is translated:

Open C:\Users\אדם\Documents\דברים\מסמך.pdf and click "Sign".

פתח את C:\Users\אדם\Documents\דברים\מסמך.pdf ולחץ על "חתימה".

Depending on your client, these should be rendered differently. If they don't, click here to see it: https://jsfiddle.net/jex3yfrw/

Edit: looks like Voyager needs a bug report! The web Lemmy seems to render it RTL (correctly) but still left-aligned which is not ideal.