This is all problem spectific, but I have found C code integrated via ctypes, cffi, or by a C extension is over 100x Python alone. Interestingly Python, Numba, and Numpy together which is a more pythonic solution can get to those speeds too.

Of course you did. Those are changing the semantics of the language. For example, things like Numpy store arrays more like how C does it than Python. That makes all the difference, not merely compiling to native code.