Kinda depends what part of the city you're moving to. The West End is different from downtown is different from the Mountain is different from East Hamilton.

There are lots of nice areas in the city but also some not-so-nice ones. I'd recommend checking out whatever area you might be moving to during the day and again at night.

Been a while since I've lived in the city, so I don't think I'm comfortable giving specific advice. In general, I always felt safer West or South of downtown than East or North of downtown but there's also been a bunch of gentrification in the neighborhoods closer to the lake, so maybe it's different now. I still know some people in the area so if you have specific questions, I could pass them along.