The Ryzen 7 5700G only supports PCIe 3.0. Your GPU is PCIe 4.0 so you may lose some frames as the connection will be downgraded to PCIe 3.0. Same for your SSD, it will be downgraded to a PCIe 3.0 connection.

I have a 6750 XT, although it's the Asus Dual version. Goes hard. I use it for 1440p gaming and it's performing well. (Has some coil whine in certain scenarios, though.)

Finally, unless you are really set on the ITX form factor it may be worth going to micro ATX. It will be cheaper and you'll get better cooling in a larger case.