First playthrough did a stealthy netrunner / silenced pistols Cool/Int/Tech Build which was effective enough, but didn't hold my interest all the way to the end of the game as it was just a bit detached from the action.

Current new playthrough is basically just a Mass Effect Vanguard with super high mobility, mantis blades, shotguns and some hacking for crowd control. Reflex/Body/Int build and having WAY more fun because the movement and damage potential is so ludicrous. Was tempted by the Sandevistan but wasn't prepared to give up hacking completely.

ETA: The fun in this build is probably best summarised by this text I sent my friend (who is also replaying) immediately after it happened yesterday:

"LET'S KICK THIS INTO HIGH GEAR!!" screamed the Tyger Claw, as I knee slid past him at 1000 mph and blasted him in the nards with my aggressively yellow shotgun.