I also avoid clickyui but I think the issue I have is that I struggle to think in terms of workspaces instead of applications. Also, I always struggled with the discipline required to keep tabs relevant to each browser instance - never mind browser state that should or should not span instances. I tried using Firefox Multi-Account Containers to help with this, but it seemed like I was spending more time adjusting and maintaining (fighting with my browser) than getting shit done.

I suspect things could be a lot better if we eliminated tabs/MDI altogether, but it'd be a huge step backwards for nearly 100% of users, so...