Do they? I remember not long ago I just had to have an ads.js file, and if the user had an adblocker this file wouldn't load.

So I just had a

var ads_enabled = true;

And I could check if the user had an adblock.

I think most people just install ublock/others and leave it default. When I tried to customize ublock all those lists and regex pushed me away, never tried again since.