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Sample size is relevant as a proportion of the difference you are looking for.
For example:
Sample A: 1.1, 1.3, 1.5, 1.2, 1.1
Sample B: 345.3, 323.4, 322.3, 355.2
Determining a statistical difference between these two groups where a meaningful difference is 20%, does not require more samples. The chance of error on making a claim that A is less than B will be quite low.
Not saying that N=18 in this case is sufficient, just stating that the number alone does not give you enough information to determine whether a claim has weight to it or not.