I still end up using programs/services such as malwarebytes and virustotal on my desktop since defender isn't perfect. I have had a few instances where a game that I download outside of places like Steam had files that are actually clean and safe given false positives. Same with any key gens I've used.

With malwarebytes and virustotal, I've had less false positives in legally obtained games I know are clean. Moreso with malwarebytes since there's seemingly almost always one engine on VT saying the file is bad regardless of what it is.

I always find that having a 3rd party check a file is better than just having defender do all the work. What one engine might claim is bad might be safe to another.