Far from being a tech wizz, I once decided I was going to push to the absolute limits an old 775 board I had around and the only concern I had was with CPU cooling, as I intended to fit the machine with a Core2 Quad.

Because the machine was built inside an SFF, putting in a larger cooler was not feaseable, unless I was to cut a hole into the side panel to accomodate it. However, spending a few more monies on the CPU for a 65W model did the trick and I managed to keep the stock cooler I was already using.