We can, but we have to work for it. When any group is no longer being systemically discriminated and have equal rights, then they're also valid comedy targets.

Like with racist jokes. They're fine in very confined groups where everyone agrees that the absurdity of the premise is part of the joke and where nobody will be made to feel unsafe by it. But to a wider audience where people might misunderstand where the joke came from, in what spirit it was told in, it's nok OK. Not only can it make people from the group being targeted feel unsafe, but it'll also embolden actual racists who'll mistake the joke as support of their beliefs.

It's a trust thing I guess. As soon as trans people can see someone crack a joke about them online and rest assured in the fact that the person telling that joke isn't voting for or otherwise enabling people who wants to take away their rights or straight up hurt them, then it'll be fine.

This protection, however, should not apply to people who make it their business to hurt or oppress other people, which is why it's always open season on nazis.