Nice to know I’m the 0.1% of some club. Wish it wasn’t this one.

Prednisone helped out immensely, but that’s a deal with the devil… Gonna pay for that if I stayed on it. Methotrexate was decent, but it would knock me on my butt and make me unreasonably short tempered the day after taking it (and that was splitting the dose up overnight). Biologics (Humira, Enbrel, Cimzia, Simponi Aria infusions) all worked for nine months, then I’d start flaring up after each dose. Rheum said my immune system was building up antibodies against the biologic proteins, and confirmed via one test (Enbrel, if I remember right, but I could be wrong).

On Rinvoq now. Does the job most days, but I’ll still flare up once every couple months. Ibuprofen helps on those days. After seeing painkillers blow out my aunt’s kidneys, I’m happy to stay off the ibuprofen as much as I can.