Child's Play is my go-to. They provide video games and consoles to hospitalized and often terminally ill children who literally can't go out and play. It was founded by the creators of Penny Arcade back in the early 2000s and so far to my knowledge hasn't had a single controversy or hint of anything nefarious. It's just nerds helping other, young, sick nerds/would-be-nerds get their nerd on.

I mean Doctors Without Borders definitely does more important work on the balance, but giving pediatric terminal cancer patients countless hours of joy isn't a trivial thing either.