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this post was submitted on 31 Mar 2024
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When you gain weight, once the fat storage cells reach capacity, your body makes more of them. When you go into ketosis, burning stored fat, the cells don't die. They shrink. So once you go off your diet they will happily plump back up again. This is why your weight will yo-yo.
Losing weight and keeping it off should be done through dietary change, regular exercise, and commitment. That's true even if fat cells are physically killed or removed as part of treatment. Anything else yields temporary results or requires a lifelong legal drug habit.
The fat storage cells definitely play a role as well. One of the ways in which the mechanism I discussed works is via leptin, as leptons regulate energy expenditure. Leptin is primarily produced by adipocytes. So, I believe that is where the connection is. This paper says some interesting stuff about it: https://doi.org/10.1242/dmm.008698.
The issue that I was discussing is that most people do not succeed with keeping the weight off. Most obese people do not manage to lose significant weight in the long term as they tend to regain the weight. We need to look at why that is to solve it. The research on setpoints offers at least a partial explanation. However, if you know about research that further explains this, I would be very interested. (Some sources if you are interested: https://pubmed.ncbi.nlm.nih.gov/17469900/, https://pubmed.ncbi.nlm.nih.gov/11684524/, https://pubmed.ncbi.nlm.nih.gov/19175510/)