Retrofitting F-16s to become drones (whether rc or ai-controlled) as well as designing a variant ditching human support for weight and monetary gains is the rational choice as long as non stealth aircraft are viable. In that case you'd stick to F-35s.

It makes no sense to waste billions worth of perfectly capable and proven airframes, engines and avionics. Any future drone that will have at least the same level of capabilities as an f-16 will cost practically cost the same. At the cost of high performance aircraft life support does not add that much cost to a plane, pilot costs (and availability) are a much bigger issue.