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Blizzard says that modding Diablo IV can result in a permanent account ban
(www.techspot.com)
This is a most excellent place for technology news and articles.
They did the same with diablo 3. Always on drm so that people couldn't use cheats to get better loot IN A SINGLE PLAYER GAME. Why? Because they want you to their market and spend real cash for stuff
This is probably the only reason they care about. It's definitely not for the "integrity of the game" or anything like that