Of course! If it has an installer, run it through Bottles first.

• Mount the ISO file in KDE/GNOME
• Create a new bottle in Bottles
• Open the bottle and select the executable on the mounted ISO to start
• When choosing an install directory, install to the Z: drive if possible so you don't have to look for the files in your Bottles prefix
• Follow the installer normally

Once done, you can either start the game directly in Bottles or create a non-Steam shortcut in Steam and select the exe of the game you just installed.

I prefer running it through Steam because then I always have access to the latest Proton versions.

Didn't try FF7 but played Alan Wake 2 like this.