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this post was submitted on 29 Jun 2023
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Obesity is one of the leading preventable causes of cancer. Along with tobacco, alcohol, sun exposure, and red meat consumption. Aspartame is not a major cause of cancer in humans. If it helps you lose weight, then you're improving your cancer risk.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515569/
If it helps you lose weight, sure, but I think there is more going on when you realize cancer risk down but mortality up...
I'm entertained by this sentence from your source (great source, by the way): "No significant associations were found for cancer mortality." Lol
Also from your source, though, to dig deeper past the study title:
"Of note, participants in the highest levels of ASB intake were more likely to be overweight/obese, hypertensive, and hypercholesterolemic in most studies (8, 10, 11, 17, 28), and thus reverse causation was possible" meaning people already experiencing health-damaging overweight/obesity are also more likely to be replacing sugar-sweetened beverages (SSB) with artificially-sweetened beverages (ASB) which confounds the result that higher ASB intake is associated with higher all cause mortality. It may simply be that people who already had high mortality risk from their weight were also more likely to be consuming large amounts of ASB.
"Meta-analyses of randomized controlled trials found that low-calorie sweeteners modestly but significantly reduced body weight, BMI, fat mass, and waist circumference (23), but had no effects on blood glucose and blood lipids compared with saccharides (39)"
"Although biological mechanisms remain inconclusive, some studies indicated detrimental effects of low-calorie sweeteners on the regulatory mechanisms of appetite and satiety, release of gastrointestinal hormones, gastric motility, and balance and diversity of gut microbiota, which may further increase energy intake and disrupt blood glucose homeostasis (40). Taken together, ASBs might be optional alternatives for SSBs only when they are consumed in small quantities for weight management, and the long-term adverse associations of high amounts of ASBs with cardiometabolic diseases and mortality should be considered"
"Based on current evidence, SSB intakes should be avoided, and if ASBs are considered as optional alternatives for SSBs, they should be consumed in small quantities (i.e., <1.5 servings/d). Nevertheless, further high-quality studies are still warranted, particularly on the long-term impact of ASB intakes, because of limited studies and low-to-moderate quality of the current evidence."
So overall, a little more nuanced and not quite the knock-out punch the study title might suggest.