Interesting idea. That would perhaps wreck a lot of pixel art, but I guess it'd be fine scaled up to 2x2 pixels as you often see it like that anyway.

If that happens, it should be a surprise - would really throw a spanner in the works and make it a unique event. The more I think about this idea, the more I like it!

Or to make it more realistic, let it expand like the universe. I.e. add extra space between each two pixels:

w=blank/white, b=non-blank
wwwww
wbbbw
wbbww
wwwww
->
wwwwwwwwww
wwwwwwwwww
wwbwbwbwww
wwwwwwwwww
wwbwbwwwww
wwwwwwwwww
wwwwwwwwww
wwwwwwwwww

Or keep non-blank pixels together, because of pixel bounds.

I like this idea. It also allows filling the previous larger art with more detail. Maybe once 50% of the Virgin pixels are used, it scales up.

i like this alot would be really interesting to see.