I've spent a good amount of time studying various DNA processes and never once made a connection between i-motifs and clippy. Great catch! lol

The thing is, our cells create these "knots" to make room for enzymes to access our DNA. They're quite common as it's required for DNA transcription + replication, chromosome segregation in cell division, telomere maintenance, and to alter gene expression. Not sure how I overlooked what happens if they form more often than intended. Wild to learn it can lead to cancer, neurodegeneration, and heart disorders! Guess I missed two massive aspects when studying all this, the imapct of DNA forming i-motifs too often, and the resemblance to clippy hahaha.