Depends on what you do.

If you're just browsing, and doing casual stuff, it's not really noticeable. It's perfect for the less technically oriented because nothing changes for years.

I've been using MX for about a year now, but I definitely wouldn't have without flatpak and nix. I need packages that aren't years out of date, so they're all installed through nix home-manager.

The benefit of this combo is that while user packages might break, the system itself will be predictable for the next few years. That means no new bugs, but also that minor issues won't be solved.