It really depends on what you're most comfortable with; when you go for such a custom option most of the design decisions are about personal preferences.

I suggest you draw out some layouts on a piece of paper, adjust them until you feel happy and then plan out how you want the keymap to look. When you're happy, look for a layout that fits what you want or build your own on KiCAD.

I bought a kyria from Splitkb, and I've been very happy with the design. If I needed another keyboard, it would probably be a very similar layout, but have slightly fewer keys, be low-profile and no oleds.