Each new planet is basically an overhaul mod. They did a great job incorporating the best parts of Space Exploration, Krastorio, Seablock, and a couple mods that either they made up entirely, or I didn't know the names of.

Also the overhauls to the fluid handling and circuit networks make everything so much easier. I'm actually learning how to use circuits and trains, and I only have about 3000 hours of gameplay in vanilla.

My best advice is to rush bots, and leave even more space in-between your modular builds. Holy crap do I have some spaghetti because of squeezing things into my bus.