https://cachyos.org/

CachyOS does compile packages with the x86-64-v3, x86-64-v4 and Zen4 instruction set and LTO to provide a higher performance. Core packages also get PGO or BOLT optimization.

CachyOS utilizes the BORE Scheduler for better interactivity, and offers a variety of scheduler options including EEVDF, sched-ext, ECHO, and RT. All kernels are compiled with optimized x86-64-v3, x86-64-v4, Zen4 instructions and LTO to be optimized for your CPU.

I like the sound of that for my new gaming distro, but I really feel more comfortable in the .deb ecosystem.