Not personally but it's been done with mixed results. Usually the application on it's own is stable but doesn't work with plugins and who knows about it's integration with USB control and MIDI devices. Depending on your setup latency can be a significant issue and vm can introduce quite a lot. Reaper is my DAW of choice for Linux but Ableton Live is what I enjoy most and make the best stuff in. I don't need a powerful machine for what I do with it though so an old laptop has always sufficed, which works out anyway because I don't care as much if it gets damaged or stolen etc. Just wish I could be a full time linuxbro :(