All the Metroid games, especially the 2D ones. If you like a good metroidvania, well, you can't go wrong with the game that created the genre.

I did not see Celeste mentioned, but if you're at least one bit into platforming, this gem is an absolute must-play. And must listen, I have the OST on repeat since it came out.

If beat them all are your jam, you need to play some P* games, and the ones with a female protagonist are the Bayonetta. Heavily sexualized, but to a point where it becomes some kind of parody of itself, you have to embrace the aesthetic. The rhythm is frantic, the scenario barely understandable, the action way over-the-top, and the combat gameplay tight as hell.

In more standard AAA waters, the two Tomb Raider reboots are pretty good, although a bit heavy on male-gaze.

Back to the indy side, What Remains of Edith Finch is a first person narrative game, in which you'll play as different characters. But the main ones are girls, and it matters in the plot.

Besides me wanting to immediately say things like Metroid, Celeste, Tomb Raider, Life is Strange and such.

Games I enjoyed

• Cat Lady / Lorelai
• DOS2 (technically you can just play Sebille and Lohse stories)
• fault milestone (incomplete)
• anything by Christine Love (visual novels)
• Transistor

Then other random games I can think of that I didn't see listed

• Fatal Frame
• Bleed
• They Bleed Pixels
• Franbow
• Beyond Good and Evil
• Beyond Two Souls
• Indivisible
• Hatsune Miku games? (lol)
• Potionomics
• Alice Madness Returns
• Tandem: A Tale of Shadows
• Gris
• Little Misfortune
• Crypt of the Necrodancer
• Neptunia series
• Saintmaker

And I should stop before I am here all day thinking... lol

beyond good and evil is great

The Last of Us: Part II !

Trying to find some that haven't been talked about yet:

Echo. It's a fantastic experimental infiltration game with an AI that adapts to your way of playing. The setup is very impressive.

Pathologic: one of the three playable characters (the Changeling). It's a bizarre russian game, with an unique world, and messy gameplay. Can't recommend it enough.

Va11 Hall-A: chill bartending game in a cyberpunk setup.

The Blackwell series: comfy, kind of amateurish point and clicks by Wadjet Eye. I like them very much.

Transistor: weirdest game by Supergiant. You play as a redhead with a talking sword. I don't remember much about it except that it was good.

The Fall: (pushing it a little bit, since the protagonist is an AI, but I've always seen here as female.) Criminally underrated puzzle games, disguised as metroidvanias.

Eliza (by Zachtronics): the only visual novel I enjoyed. It's hard to explain, it's about AI, burnout, whether tech dehumanizes people, and solitaire.

Hedon Duology: for something completely different, it's a slightly kinky retroshooter, with amazon Orcs fighting demons.
It may sound a bit dumb, but it's excellent. Huge levels, interesting worldbuilding, and a gameplay based on exploration, puzzles as well as shooting.

There's probably a ton more, but that's all I can think about at the moment.

Jade from Beyond Good and Evil.

Alien Isolation

Resident Evil Remake 2 and 3, great games with both male and female protagonists!

Cyberpunk!

Whoa whoa whats wrong with Senua?

Don't see it mentioned yet, it's an older game but Remember Me is pretty good

Can I suggest some great novel games?

**VA-11 HALL-A: Cyberpunk Bartender Action **

• play as a bartender and change outcomes of stories by providing different drinks

Fatal Twelve

• death game, mystery, lesbian couple as main character, one of the best

A group of developers have created a version of the game and it's sequels that runs on modern machines: http://nolfrevival.tk/

Edit: this was meant as a reply to @KIM_JING_JUICEBOX 's comment. No One Lives Forever is a whip smart spy FPS that nails the Bond aesthetic but stars an unforgettable female protagonist, Kate Archer. Download it for free above.

Aquaria

A very well put together Metroidvania. The map is very fun to explore, good boss fights, great music, and interesting story.

Silent Hill 3 has a great female protagonist imo, but you have to play Silent Hill 1 to get the gist of the story in 3.

Night in the Woods is objectively the best game ever made by any measure. Tacoma and Gone Home are amazing too.

I mean I dunno, it depends on what kind of games you like, surely?

Plague Tale:Innocence and Requiem

Forspoken isn't bad.... As long as it's played completely dubbed in Japanese with subs on. Obviously last of us 2 was really great, horizon is also very well acted, and very well done. I think it also is inclusive in a way that matters where some games just replace the protag with a woman, these games build it into narrative as well. In the same vein, I really liked life is strange (even colors to be honest)

Most games I can think of have been mentioned, but I found Signalis to be an interesting experience assuming you can get past the annoying inventory management

I'm having a great time finally getting into What Remains of Edith Finch.

Control is excellent

Not female, but the protagonist of Outer Wilds is nonbinary, as is their entire species.

A few more that may not be mentioned:

Dandara - fun platformer

Ion Fury - throwback to 90s shooters, good if you can handle some juvenile humor.

Knights and Bikes - played through with my daughter and we loved it.

Spiritfarer - low pressure gameplay, story and exploration focused (edit: sorry, runekn already mentioned this one)

Final Fantasy X-2 comes to mind. I didn't finish it, but it's well-reviewed so...

It Takes Two has a great protagonist

Surprised no one has mentioned Tomb Raider yet. Others not yet mentioned:

• Assassin's Creed: Liberation, and Chronicles: China
• Beyond: Two Souls
• The Last of Us Part II
• inFamous: First Light

Alien: Isolation!

Going Under. It's a goofy rougelike game which parodizes corporate companies and startups. You play as an unpaid marketing intern who needs to kill monsters from failed startups, but she applied for marketing,

Stardew valley is fun

"good" is subjective, but I can recommend the Tomb Raider reboots.