if you only play one card, you can hold more steel/gold/blue seal cards in your hand

this doesn't matter much for winning normal runs, but if you happen to get jokers that buff steel cards (i.e. Mime and Baron), copy said jokers, find ways to increase your hand size, and make every card in your deck the same card, you can get absurdly high scores and get really far into endless mode

my current high score is 6.817x10^98, which I got with a really good high card plasma deck run

again though, you do need to find exactly the right jokers for this, so building around any other hand type is almost always more reliable for winning ante 8