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Out of the Abyss has been interesting as a first time DM
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Whenever something seems to be moving towards a TPK, I make sure the players have some sort of reasonable escape. There may be one or two PC deaths, but nothing crazy. I think I ran OOTA with only 2 PC deaths for the whole campaign.
The other thing is that OOTA specifically gives you lots of NPCs at the start so they can take the brunt of the deaths.