I have a simple planck eotb, and carry it everywhere I go. It's really convenient. I think I got used to typing on it in only a couple of weeks, but spend the past few years tweaking my custom ambidextrous layout.

Some of my personal favorites are:

• having backspace+ctrl combined on one key, enter+shift combined on another key.
• Having enter and backspace on both sides of the keyboard, so I can use either hand to use them
• Having a single hand numpad when holding a layer key. Very practical for number stuff.
• Putting any computer to sleep, or changing volume without having to look for the right key on my keyboard.