Definitely get your side panel set up, it's nice to have things like chathub, notes, and any website you don't need for long periods of time (I keep fandom wiki pages for all the crafting games I play like Valheim in the side bar for quick information on items and components.)

There's also the three different tab stacking options to choose from and a nice theme UI editor built in. As long as you chose block trackers and ads you should be pretty good on that without needing UBO. I don't see anything on YT and that's just with stock V.