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this post was submitted on 16 Jun 2025
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What you really need is one of native DAWs you mentioned combined with Windows VST plugins run using Yabridge + WINE.
I remember running even complex VSTs along with realtime MIDI processing from e-drums with really good results and low latency.
Make sure your distro runs Pipewire and has pipewire-jack installed. Run your DAWs with JACK backend
You can check https://wiki.archlinux.org/title/Professional_audio for tips regarding audio performance. Don't worry if you don’t use Arch-based distro. Most of it applies to any distro really
Install wine and yabridge follow setup instructions on how sync your plugins, which essentially takes specified locations with VST2/VST3 DLLs and creates .so equivalents (Linux dll format) under specified location that under the hood calls Wine, but makes it transparent. You add that location (with .so files) in your DAWs search paths and it should scan those plugins like if they were native.
Of course some compatibility issues are possible, but you should be able to run most stuff this way when it comes to plugins.