I recently started playing around with Reaper on Linux. It's no different from it's windows counterpart. You can use something like yabridge to use third party VSTs. All I had to do was point it to my VST folder and viola, almost all of them work. The only problem I have is that none of them work graphically. The sound works and they render just fine but for some reason clicking on a knob or button is waaaay off. For example in Pro-Q, if I put the mouse by the top of the plugin the frequency knob will highlight like the mouse is on top of knob. Nothing happens if the mouse is actually on top. This may be a yabridge issue. Their GitHub does say Wine versions greater than 9.22 don't work. I'm on the latest Wine and haven't fucked with different versions yet. If the fix is that simple then the experience is no different for me at least. Otherwise I just have to use the UI-less mode where Reaper turns the plugins into a series of sliders you can adjust instead.