I've only had problems with two games.

A game called OneShot, which has some meta things as part of the game. Like, it's supposed to change your wallpaper and such "outside the game" things. No biggy, just had to run an executable with a specific version on Wine and it worked as intended.

The other was Vermitide 2, never got around to finding a solution for that one, as I honestly didn't care enough to find out what the problem is.

Everything else has worked splendidly.

Addendum: getting Blizzards Launcher work was a bitch though. Thankfully, Steam provides.