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Syncthing 2.0 Launches With Major Database Overhaul
(linuxiac.com)
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I don't think your use will be effected. I believe the only thing is your database will be less bloated with deleted items that have never been removed previously.
If you add a file back after it's removed from the database, It should sync as usual.
(This is my interpretation of the change notes, i'm no experto, maybe a real experto can confirm this is true or not).