I have like 1.5k tabs, I find ones I need because it suggests open tabs in the address bar. If I need to go from my first few tabs to something at the end or vice versa, I click on one of my pinned tabs which stays at the beginning and is always visible (doesn't scroll) and then use the hotkey to go to next / prev tab which wraps and immediately scrolls to the end. It's a lot faster than using the scroll wheel. That's my main tab group, I have like 6 or 7 others with around 500 tabs each