They'd probably respond similarly to telling somebody who was circumcised without consent and doesn't like it that it's just a harmless cosmetic surgery. Or telling a trans person forced to experience the wrong puberty that it isn't a big deal/we can't allow trans kids to go on puberty blockers because they might regret it (despite the fact that all the effects of puberty blockers are reversed by...stopping taking them).

Source: am trans, was forced through the wrong puberty, and was circumcised without consent as a baby and hate it. Did you know that there are people out there so traumatized by being circumcised as a baby that they willingly use clamps and rubber bands to slowly stretch out the skin on their dick until it looks like a foreskin again? The info on how to do it is easily accessible online and the tools are easily purchased. I know this because I discovered it and considered it not long before I discovered words like "transgender" and "gender dysphoria" and found out that there were words for feelings that I did not have the language to understand before.

I used those specific body parts as examples for a few reasons. Namely, they're all designed to protect mucus membranes and keep them moist, like the foreskin. Removing them would also be permanent and result in negative effects - like how circumcision causes nerve damage and desensitization. There really isn't a great comparison, and those who had it done as a kid don't know what they're missing. We do have plenty of reports from people who had it done later in life, though, and there's plenty of data on the loss of sensitivity and struggle with sexual pleasure and satisfaction post-circumcision.

I guess the closest thing would be if people were ritualistically shooting lasers into their babies' eyes to damage the lenses so that they needed glasses or something. Some people just like the way that glasses look. I knew a guy who didn't need glasses and wore a pair without any lenses in them just because he liked the way that they looked. But given the choice between glasses and 20/20 vision, I'd personally take the 20/20 vision, thanks.