Anti-Aging Injection Regrows Knee Cartilage and Prevents Arthritis (scitechdaily.com)

submitted 1 week ago by Lemmar@lemmy.today to c/science@lemmy.world

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In mice (of course) and human tissue exvivo. Earlier phase 1 studies with 15-PGDH has shown that it is safe and active in healthy volunteers.

Reference: “Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration” by Mamta Singla, Yu Xin Wang, Elena Monti, Yudhishtar Bedi, Pranay Agarwal, Shiqi Su, Sara Ancel, Maiko Hermsmeier, Nitya Devisetti, Akshay Pandey, Mohsen Afshar Bakooshli, Adelaida R. Palla, Stuart Goodman, Helen M Blau and Nidhi Bhutani, 27 November 2025, Science. DOI: 10.1126/science.adx6649

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[-] Lemmyoutofhere@lemmy.ca 14 points 1 week ago

As a 50+ year old mechanic, this can’t come soon enough.

[-] hanrahan@piefed.social 3 points 1 week ago

Thank you for doing useful work

[-] SaveTheTuaHawk@lemmy.ca 0 points 1 week ago

Spoiler alert: you can't afford it.

[-] Dupelet@piefed.social 4 points 1 week ago

Speak for the Americans. The rest of us have no trouble doing so

[-] rumba@lemmy.zip 1 points 1 week ago

also cancer :)

Any of the "regrows damage" side of thing scares the fuck out of me. I mean I want it to come and ASAP, but I also don't want to play chicken with C

[-] Lemmyoutofhere@lemmy.ca -2 points 1 week ago

Cancer is largely based on your genetics, except for extreme causes like asbestos or smoking. It’s worth the risk.

[-] rumba@lemmy.zip 1 points 1 week ago

Not in this case.

"Stem cells survive much longer than ordinary cells, increasing the chance that they might accumulate genetic mutations. It might take only a few mutations for one cell to lose control over its self-renewal and growth and become the source of cancer."

https://www.hsci.harvard.edu/stem-cells-and-cancer

[-] chonglibloodsport@lemmy.world 0 points 1 week ago

Wow yes. So many older and retired workers from the skilled trades could benefit from this.

It would also be a huge boon for recruitment as I imagine young people considering the career may be discouraged by the physical demands of the job and their potential lasting effects.