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submitted 1 week ago by Lemmar@lemmy.today to c/science@lemmy.world

In mice (of course) and human tissue exvivo. Earlier phase 1 studies with 15-PGDH has shown that it is safe and active in healthy volunteers.

Reference: “Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration” by Mamta Singla, Yu Xin Wang, Elena Monti, Yudhishtar Bedi, Pranay Agarwal, Shiqi Su, Sara Ancel, Maiko Hermsmeier, Nitya Devisetti, Akshay Pandey, Mohsen Afshar Bakooshli, Adelaida R. Palla, Stuart Goodman, Helen M Blau and Nidhi Bhutani, 27 November 2025, Science. DOI: 10.1126/science.adx6649

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[-] Lemmyoutofhere@lemmy.ca 14 points 1 week ago

As a 50+ year old mechanic, this can’t come soon enough.

[-] hanrahan@piefed.social 3 points 1 week ago

Thank you for doing useful work

[-] chonglibloodsport@lemmy.world 0 points 1 week ago

Wow yes. So many older and retired workers from the skilled trades could benefit from this.

It would also be a huge boon for recruitment as I imagine young people considering the career may be discouraged by the physical demands of the job and their potential lasting effects.

[-] Damage@feddit.it 2 points 1 week ago

Arthritis is not limited to trade workers, anyone can have it.

And it isn't the only health issue physical work can cause.

[-] roofuskit@lemmy.world 0 points 1 week ago

Perfect for making you work the remainder of your life. No more arthritis? Great, now work until death to pay for it.

[-] explodicle@sh.itjust.works 3 points 1 week ago

Honestly I'd take that over this arthritis

[-] Dupelet@piefed.social 3 points 1 week ago
[-] roofuskit@lemmy.world 1 points 1 week ago

Or win the lottery.

[-] angrystego@lemmy.world 2 points 1 week ago

I don't think arthritis is the win you think it is.

[-] SaveTheTuaHawk@lemmy.ca 0 points 1 week ago

Spoiler alert: you can't afford it.

[-] Dupelet@piefed.social 4 points 1 week ago

Speak for the Americans. The rest of us have no trouble doing so

[-] rumba@lemmy.zip 1 points 1 week ago

also cancer :)

Any of the "regrows damage" side of thing scares the fuck out of me. I mean I want it to come and ASAP, but I also don't want to play chicken with C

[-] Lemmyoutofhere@lemmy.ca -2 points 1 week ago

Cancer is largely based on your genetics, except for extreme causes like asbestos or smoking. It’s worth the risk.

[-] rumba@lemmy.zip 1 points 1 week ago

Not in this case.

"Stem cells survive much longer than ordinary cells, increasing the chance that they might accumulate genetic mutations. It might take only a few mutations for one cell to lose control over its self-renewal and growth and become the source of cancer."

https://www.hsci.harvard.edu/stem-cells-and-cancer

[-] NoTagBacks@lemmy.dbzer0.com 9 points 1 week ago

Holy shit. Directly treating the cause of cartilage loss with pill-form treatment in human trials right now. The shit we've been doing with medical science recently is fucking wild.

[-] veroxii@aussie.zone 2 points 1 week ago

Would've been useful before I had my foot cut off. 🤷‍♂️

[-] ChairmanMeow@programming.dev 3 points 1 week ago

In 20 years you'll get a pill from the pharmacy to grow a new one 😋

[-] Maeve@kbin.earth 1 points 1 week ago
[-] 87Six@lemmy.zip 2 points 1 week ago

TONIGHT ON DEAL OR NO DEAL:

you can get this new leg but it will cost you a kidney

[-] MrShankles@reddthat.com 2 points 1 week ago

I only need one kidney, AND I can have 3 legs. Deal

[-] Hazy@aussie.zone 1 points 1 week ago

I already have 3 😏

[-] ChairmanMeow@programming.dev 1 points 1 week ago

It might cost you an arm and a leg.

[-] FlashMobOfOne@lemmy.world 2 points 1 week ago

This summer we'll find out the results of the Galleri test trials in the UK. Another game changer potentially.

[-] Grandwolf319@sh.itjust.works 3 points 1 week ago

Between this and growing new teeth, things are looking a lot more cyberpunk than before.

[-] Lawnman23@lemmy.world 1 points 1 week ago
[-] Waraugh@lemmy.dbzer0.com 1 points 1 week ago

Is that from a game? Kind of looks like Keanu Reeves

[-] Grandwolf319@sh.itjust.works 1 points 1 week ago

Yes and yes.

Cyberpunk 77

[-] Damage@feddit.it 1 points 1 week ago* (last edited 1 week ago)

Cyberpunk 2077, and yeah, it's Keanu Reeves as Johnny Silverhand.

They've got Idris Elba too in the DLC.

[-] Sharkticon@lemmy.zip 1 points 1 week ago

In that only the upper wealthy class will be able to afford it?

[-] popekingjoe@lemmy.world 2 points 1 week ago
[-] SocialMediaRefugee@lemmy.world 2 points 1 week ago

I wonder if you'd have to stay off of those joints for months to allow the regrowth to occur properly.

[-] Mac@mander.xyz 1 points 1 week ago

The rich are going to live well

[-] Dupelet@piefed.social 1 points 1 week ago

So are non Americans

[-] Smoogs@lemmy.world 1 points 1 week ago

So…there’s a chance I can back into martial arts? Bring it.

[-] stringere@sh.itjust.works 1 points 1 week ago

Martial arts should probably be approached from the front, but you do you, boo.

[-] SkunkWorkz@lemmy.world 0 points 1 week ago

Bet soon I can buy this from a roided up guy in the locker rooms of my local gym. Middle aged power lifters would love to pop these pills.

[-] Lemmar@lemmy.today 1 points 1 week ago

Most definitely. I'm almost in that demographic myself and several of the slightly older, nerdy lifters at my gym talk about BPC-157 as something they would consider using.

If this gets proven to work in vivo in humans I'm certain we'll see the same no matter side effects.

[-] musubibreakfast@lemmy.world 1 points 1 week ago

"I just popped a kneecap, it shot clean off and broke a mirror. Pill me babay!"

[-] SocialMediaRefugee@lemmy.world 0 points 1 week ago* (last edited 1 week ago)

The question is "Does 15-PGDH do something beneficial and would suppressing it have serious side effects?"

I found this:

15-HPGD has an unappreciated role in the maintenance of pregnancy. In mice, 15-HPDG has been shown to have essential roles in prevention of early termination of pregnancy and maternal morbidity. In 15-HPGD knockout mice, early pregnancy termination was detected.

So any 15-HPGD treatment would have to be done with careful consideration of woman of reproductive age.

[-] Taleya@aussie.zone 2 points 1 week ago

reproductive urge, you mean.

Plenty of women with the equipment and no intention of using it.

[-] angrystego@lemmy.world 1 points 1 week ago

Well, that's part of what you'd have to consider. The reply didn't state it would be contraindicated in reproductive age, just that it shouldn't be applied without consideration.

[-] wabafee@lemmy.world 0 points 1 week ago

Damn mice's at this point they will reach immortality first. Then again thankful for that lol.

[-] pulsewidth@lemmy.world 1 points 1 week ago

They'll deserve it, the shit we've put them through.

I feel there's very little the rest of the world should emulate of modern Russia, but this is one example that I would like to see mimicry of: https://en.wikipedia.org/wiki/Monument_to_the_laboratory_mouse

this post was submitted on 04 Jan 2026
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