Maybe some instances can be de-federated if it's shown over time that they exist specifically for that purpose, but on a platform level I don't think anything can be done, not without messing up the core feature of it at least which is decentralization through ActivityPub.

It's inevitable that it will happen as popularity increases and certain organizations become aware of it, it will have to be a constant struggle unfortunately, similar to socialist states existing alongside aggressive capitalist ones.