This started happening a few months ago, I would be minding my own Ubuntu business and then suddenly I can't left click.

After much digging and stupid AI querying, I added something to disabled power management to my boot sequence. That seems to minimize the problems but I still get the problem every 5 minutes or so.

To temporarily fix the problem I Ctrl-alt F3 then F2 to come back to. GNOME.

I tried with a mint usb and I got the same problem. I thought it was then maybe a mouse problem but the pointer does the same no matter what mouse I use and every mouse I tested worked fine on another Ubuntu of the same release. So I think maybe it is some sort of hardware and driver combination and to power management.

I see lots of posts of past years but nothing more recently, but no real solutions or explanations for what might be happening.

Okay looks like a start up script will be the thing to do next.