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this post was submitted on 20 Feb 2026
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Asklemmy
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Microdosing, to me, means microdosing. Not low dosing.
If you want it to stay effective, and not build tolerance, and whatever other skewed bio-homeostasis effects, I suggest go down to single figure mg, or, even as the name suggests, into micrograms range. Try 100x-1000x less. Maybe try a break for months to reset to make microdosing effective again.
Can boost wellbeing/parasympathetic/braingrowth/healing effects with adaptogens (like ashvagandha) and other neurogens (like lion's mane mushroom/mycelia), and cannabinoids (like max dose CBD, 1200mg), and vitamins (whatever you're missing, fat soluble, B, C, etc) and magnesium (glycinate). This will keep it working good, better, for longer.